What is the mechanism of quinolones?
The mechanism of quinolone inhibition occurs via formation of a ternary cleavage complex with the topoisomerase enzyme and DNA Figure 2 (Hiasa and Shea, 2000). However, the molecular details of the mode of action of these drugs remain unclear.
What are quinolones?
Quinolones are broad-spectrum antibiotics that are active against both Gram-positive and Gram-negative bacteria, including mycobacteria, and anaerobes.
What are examples of quinolones?
Indications for Quinolone Antibiotics Labeled by the U.S. Food and Drug Administration
| Indications | Agents |
|---|---|
| Infectious diarrhea | Ciprofloxacin |
| Typhoid fever | Ciprofloxacin |
| Prostatitis | Norfloxacin, ofloxacin, trovafloxacin* |
| Acute sinusitis | Ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin (Avelox), trovafloxacin* |
What are the side effects of quinolones?
Abstract. Fluoroquinolones are generally very safe antibiotics which do not cause serious or life-threatening adverse reactions. The most frequent side-effects are gastrointestinal reactions (nausea, dyspepsia, vomiting) and CNS reactions such as dizziness, insomnia and headache.
What are quinolones made from?
Nearly all quinolone antibiotics in use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are effective against both Gram-negative and Gram-positive bacteria. One example is ciprofloxacin, one of the most widely used antibiotics worldwide.
What are the indication for quinolones?
Is quinolones bacteriostatic or bactericidal?
Quinolones are chemotherapeutic bactericidal drugs. They interfere with DNA replication by preventing bacterial DNA from unwinding and duplicating.
Are quinolones safe?
Generally, these drugs are well tolerated and have proven to be safe and efficacious antimicrobial agents. Fluoroquinolones continue to be contraindicated for pregnant women; however, a growing body of evidence suggests that these drugs are safe in children.
How are quinolones made?
Quinolones are molecules structurally derived from the heterobicyclic aromatic compound quinoline, the name of which originated from the oily substance obtained after the alkaline distillation of quinine (Gerhardt, 1842).