What does TGFB1 do?
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.
Which genes are part of the TGFB1 pathway?
The genes involved in the TGF-β signaling pathway include the SMAD2, SMAD3, SMAD4, transforming growth factor beta 1 (TGFB1), TGFB2, TGFB3, transforming growth factor beta receptor 1 (TGFBR1), and TGFBR2 genes. The SMAD2, SMAD3, and SMAD4 genes are located on chromosome 18q21. 1, 15q22.
What is TGFB1 gene?
TGFB1 (Transforming Growth Factor Beta 1) is a Protein Coding gene. Diseases associated with TGFB1 include Camurati-Engelmann Disease and Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and CREB Pathway.
What does a high TGF-beta 1 mean?
What does it mean if your TGF-b1 result is too high? – TGF B-1 is often chronically over-expressed in disease states, including cancer, fibrosis and inflammation. – TGF B-1 is moderately to extremely high in Chronic Inflammatory Response Syndrome due to water-damaged buildings (CIRS).
What does it mean if TGF beta 1 is high?
Is TGFB1 a cytokine?
Transforming growth factor beta 1 (TGFB1) is a cytokine that acts as a central regulator of the inflammatory response; thus, it is a logical biological candidate gene for COPD.
What is the difference between TGF beta 1 and 2?
TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems.
Is TGF beta a tumor suppressor?
TGF-β is a potent proliferation inhibitor of normal colon epithelial cells and acts as a tumor suppressor. However, TGF-β also promotes invasion and metastasis during late-stage CRC, thereby acting as an oncogene.