Which is better rifampin or isoniazid?
The current standard treatment — 9 months of isoniazid — has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer and to have higher completion rates than 9 months of isoniazid.
How effective is isoniazid for TB?
Isoniazid was effective in preventing TB in 60% of people, although some did develop hepatitis. The findings showed that one person can be saved from getting TB when 35 people take isoniazid for six months, and one in every 200 treated will get hepatitis.
How effective is isoniazid and rifapentine?
Conclusions. The use of rifapentine plus isoniazid for 3 months was as effective as 9 months of isoniazid alone in preventing tuberculosis and had a higher treatment-completion rate. Long-term safety monitoring will be important.
Is rifampin safer than isoniazid?
Rifampicin May Be Safer Than Isoniazid in Latent Tuberculosis Treatment. This detailed analysis of safety data shows that the incidence of grade 1 to 2 rash or any grade 3 to 5 adverse event is 1.2% lower among those receiving 4 months of daily rifampicin than in those receiving 9 months of daily isoniazid.
How long should isoniazid be taken?
To help clear up your tuberculosis (TB) completely, it is very important that you keep taking this medicine for the full time of treatment, even if you begin to feel better after a few weeks. You may have to take it every day for as long as 6 months to 2 years. It is important that you do not miss any doses.
How is latent TB treated?
A course of antibiotic medicine will treat latent TB. You may be given Rifampicin and Isoniazid for three months (which may be together in a tablet called Rifinah) or Isoniazid by itself for six months. Your doctor or TB specialist nurse will talk you through the treatment and answer any questions you may have.