Which drugs require therapeutic drug monitoring?
Introduction. Therapeutic Drug Monitoring aims to individualise drug therapy and avoid both sub- therapeutic and toxic plasma drug concentrations.
What is the need for therapeutic drug monitoring?
Therapeutic drug monitoring helps in designing patient-specific dosage regimen; it aids in enhancing the efficacy of drugs, to reduce the toxicity of drugs and for diagnostic purposes, by individualizing drug therapy.
Does metformin need therapeutic drug monitoring?
Therefore, therapeutic drug monitoring (TDM) of metformin is required as an effort to ascertain that metformin concentration is within the recommended therapeutic range.
Does paracetamol require therapeutic drug monitoring?
Paracetamol concentrations should be assessed in all patients who have ingested a potentially dangerous dose of paracetamol or if there is reasonable clinical suspicion that this has occurred. The sample should be taken at least 4 h after ingestion at which time paracetamol has generally been fully absorbed.
What are therapeutic drugs used for?
The purpose of using drugs is to relieve symptoms, treat infection, reduce the risk of future disease, and destroy selected cells such as in the chemotherapeutic treatment of cancer.
What labs do you monitor with metformin?
Monitoring for any oral antidiabetic agent includes fasting blood glucose, postprandial blood glucose, and hemoglobin A1C (HbA1c) every 3 to 6 months.
What is the antidote for metformin?
Treatment of metformin poisoning is symptomatic and supportive and there is no antidote available. Typical treatment strategies consist of correcting acidosis with intravenous sodium bicarbonate and decreasing the blood levels of metformin.
Why TDM is required for digoxin?
For effective and safe treatment with digoxin, therapeutic drug monitoring (TDM) should be performed because of its complex pharmacokinetic profile, narrow therapeutic index and extensive toxicity profile.
Do you need to monitor carbamazepine levels?
After starting carbamazepine, serum levels should be measured frequently, for example every three, six, and nine weeks. Then, carbamazepine levels should be monitored every two to three months thereafter or after a CYP3A4 inhibitor/inducer is added.