When was Lotronex taken off the market?
Lotronex was taken off the market in November 2000, less than 10 months after it was approved, because it was linked to severe intestinal problems and several deaths.
What is the generic for Lotronex?
Lotronex (Generic: Alosetron) IBS Drug Side Effects and Dosage.
What schedule is Lotronex?
To lower the risk of constipation, Lotronex should be started at a dosage of 0.5 mg twice a day. Patients who become constipated at this dosage should stop taking Lotronex until the constipation resolves. They may be restarted at 0.5 mg once a day.
Is Lotronex still on the market?
Alosetron hydrochloride (Lotronex), a prescription drug manufactured by GlaxoWellcome, and used to treat irritable bowel syndrome in women, has been withdrawn after reports of serious complications.
Why was Alosetron taken off the market?
Glaxo’s decision to pull the drug comes after further FDA analysis of post-marketing reports of patients taking alosetron, including 49 cases of ischemic colitis and 21 cases of severe constipation, resulting in 34 hospitalizations without surgery, 10 surgeries, and three deaths.
How much does Lotronex cost?
The cost for Lotronex oral tablet 0.5 mg is around $1,224 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Why was alosetron removed from the market?
Lotronex® (alosetron hydrochloride) was originally approved for IBS in the United States, and then removed from the market in 2000 due to serious gastrointestinal adverse events, some fatal.
Why was alosetron taken off the market?
What is the adverse outcome of Alosetron?
Alosetron may cause serious gastrointestinal (GI; affecting the stomach or intestines) side effects including ischemic colitis (decreased blood flow to the bowels) and severe constipation that may need to be treated in a hospital and may rarely cause death.