What should I monitor with octreotide?
Additionally, various markers are specific indicators of the therapeutic effect of octreotide and the body’s response to drug therapy. In the treatment of acromegaly, serum growth hormone (GH) and insulin-like growth factor (IGF) require monitoring.
Can octreotide cause hypotension?
These results indicate that the pressor effect of octreotide is sufficiently potent to prevent orthostatic hypotension in some patients with autonomic neuropathy. Others require treatment with both dihydroergotamine and octreotide to achieve a stable upright blood pressure.
What happens if you give too much Sandostatin?
What happens if I overdose on Octreotide (Sandostatin)? Overdose symptoms may include severe upper stomach pain, diarrhea, weight loss, warmth or tingling, numbness or cold feeling, unexplained muscle pain, weakness, weak pulse, fainting, or slow breathing (breathing may stop).
What is octreotide injection used for?
Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors (eg, vasoactive intestinal peptide tumors or VIPomas) or metastatic carcinoid tumors (tumors that has already spread in the body).
Which adverse effects are possible from octreotide therapy?
Octreotide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- pale, bulky, foul-smelling stools.
- constantly feeling the need to empty the bowels.
- stomach pain.
How fast can octreotide be given IV?
Intravenous Administration In emergency situations, octreotide may be administered undiluted by intermittent direct IV injection. Give IV slowly over 3 minutes. Dilute in 50 mL to 200 mL of 0.9% Sodium Chloride or 5% Dextrose injection; infuse IV over 15 to 30 minutes.
Does octreotide affect blood pressure?
Octreotide treatment is associated with an increase of 24-h and nighttime blood pressure, and with loss of circadian blood pressure rhythm. Splanchnic vasoconstriction by this drug, shifting blood to peripheral vessels, may explain this phenomenon.
Which major side effect is associated with octreotide?
SIDE EFFECTS: Nausea, vomiting, loose/oily stools, constipation, stomach upset, or gas may occur. Pain and irritation at the injection site may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can octreotide be given IV?
Octreotide may be administered directly by subcutaneous (s.c.) injection or by intravenous (i.v.) infusion after dilution.
Can you give octreotide IV push?