What is the most important side effect of propofol?
Common side effects of Propofol include: Low blood pressure (hypotension) Pauses in breathing (apnea) lasting 30-60 seconds. Pauses in breathing (apnea) lasting more than 60 sec.
Does propofol cause water retention?
Conclusions: Moderate propofol sedation decreases water-retaining ability but has no effect on voluntary swallowing.
How long does it take for the effects of propofol to wear off?
The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.
What are the complications of propofol?
Abstract. High-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death. The death of a patient with such complications after lung biopsy is reported.
What helps with urinary retention after surgery?
Nonpharmacologically: early ambulation after surgery and placement of a suprapubic hot pack has been shown to reduce the risk of POUR. Treatment of POUR includes initiation of selective alpha blockade (i.e., tamsulosin) and bladder decompression with either an indwelling catheter or intermittent catheterization.
How long does conscious sedation stay in your system?
The immediate effect of the IV Moderate Sedation drugs will wear off in the first several hours after your sedation appointment. We advise our patients to allow for 24 hours to fully recover from the anesthesia.
Can propofol cause kidney damage?
This medicine may cause propofol infusion syndrome, which can lead to more serious problems (eg, high potassium in the blood, high fat or cholesterol in the blood, rhabdomyolysis, enlarged liver, kidney failure, heart failure).
How can propofol infusion syndrome be prevented?
However, we must emphasize that given the high mortality of propofol infusion syndrome, the best management is prevention. Clinicians should consider alternative sedative regimes to prolonged propofol infusions and remain within recommended maximal dose limits.