What is microemulsion formulation?
MEs are water based formulations with a very small emulsified droplet size; this makes the formulation transparent. They are thermodynamically stable over a wide temperature range due to this very fine droplet size, usually between 0.01 and 0.05 μm.
What is capryol 90?
A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS.
What is propylene glycol Monocaprylate?
Propylene glycol monocaprylate is a medium-chain fatty acid ester of polyhydric alcohols. It is widely used in drugs and cosmetics as a solubilizer and emulsifier.
What is the difference between emulsion and microemulsion?
Emulsions are stable dispersions of immiscible liquids, but they are not thermodynamically stable. We say that they are kinetically stable. These type of dispersions are sometimes called macroemulsions. Microemulsions, on the other hand, are thermodynamically stable.
What is labrafil?
A solid co-emulsifier in topical formulations to improve stability of emulsions. A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly soluble APIs.
What is Maisine CC?
A winterized oil composed of long-chain mono-, di-, and triglycerides for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble lipophilic APIs. Used in self-emulsifying lipid formulations (SEDDS and SMEDDS) as an oily vehicle.
What is water in oil microemulsion?
Introduction: A water-in-oil microemulsion is a thermodynamically stable emulsion that has the capacity to ‘hide’ water-soluble molecules within a continuous oil phase.
What is the dissolution rate of capryol?
In particular, formulations A-1 (Capryol ® 90/Tween 20/Transcutol ® HP = 10%/70%/20% w / w) and B-1 (Capryol ® 90/Tween 20/PEG 200 = 10%/70%/20% w / w) with desirabilities of 0.905 and 1.000, respectively, showed low droplet size and the dissolution rate exceeded 95% at 15 and 60 min.
What is the concentration of capryol in human cells?
The Capryol ® 90, Tween 20, and Transcutol ® HP (or PEG 200) concentrations were ranged from 10 to 30%, from 30 to 70%, and from 20 to 50%, respectively. The statistical experimental model was designed using Design-Expert software (V. 10.0; Stat-Ease Inc., Minneapolis, MN, USA).
What is the dissolution rate of Transcutol hp?
The optimized formulations A-1 (Capryol ® 90/Tween 20/Transcutol ® HP = 10%/70%/20% w / w) and B-1 (Capryol ® 90/Tween 20/PEG 200 = 10%/70%/20% w / w) with desirabilities of 0.905 and 1.000, respectively, showed low droplet size and the dissolution rate exceeded 95% at 15 and 60 min.