What is methyl tetrahydrofolate?
L-5-methyl-tetrahydrofolate (L-5-methyl-THF) is the predominant form of dietary folate and the only species normally found in the circulation, and hence it is the folate that is normally transported into peripheral tissues to be used for cellular metabolism.
What is methylfolate used for?
About L-Methylfolate LEVOMEFOLATE is a B vitamin. It can be used to treat or prevent low levels of folate in the body. It is also used to help manage depression or mood in patients with low folate levels who are already taking an antidepressant or mental health medication.
Is methyl folate the same as vitamin B12?
Methylfolate and methyl B12 are the active forms of folate and B12. It is these forms that are available to be used immediately by the body without further conversion. Methylcobalamin is an active form of vitamin B12 essential for the proper synthesis of methionine and S-adenosylmethionine.
When should I take methylfolate?
L-methylfolate can be taken morning or night, with or without food. The benefits usually take effect within 2-4 weeks. Important: do not take regular folate (or folic acid) supplements with L-methylfolate, as they can prevent its absorption in the brain.
What is tetrahydrofolate used for?
Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
What is the importance of tetrahydrofolate?
Because tetrahydrofolate is required for purine and pyrimidine synthesis, its deficiency can lead to inhibition of DNA, RNA, and protein synthesis, which are essential for the growth and survival of both normal cells and cancer cells.
Should I take B12 with methylfolate?
On a basic level, you can supplement with B12 and methylfolate. Most people who have MTHFR benefit from taking methylcobalamin (methylated B12).
