What is high grade DCIS with comedo necrosis?
High-grade DCIS has a higher risk of coming back than low- or moderate-grade DCIS. High-grade DCIS may be described as comedo or comedo necrosis, which means there are areas of dead cancer cells inside the DCIS.
What is comedo type DCIS?
Comedo-DCIS is a histologic subtype of preinvasive breast neoplasia that is characterized by prominent apoptotic cell death and has greater malignant potential than other DCIS subtypes. We investigated the mechanisms of apoptosis in comedo-DCIS and its role in conversion of comedo-DCIS to invasive cancer.
What stage cancer is high grade DCIS?
DCIS that is high grade, is nuclear grade 3, or has a high mitotic rate is more likely to come back (recur) after it is removed with surgery. DCIS that is low grade, is nuclear grade 1, or has a low mitotic rate is less likely to come back after surgery.
How long does it take for high grade DCIS to become invasive?
High grade DCIS has a higher risk of becoming invasive cancer within five years after diagnosis, and has a higher risk of recurring after treatment than low or intermediate grade.
What does comedo necrosis mean?
Answer: The term ‘necrosis’ refers to cells that are dying. When cells die, they often attract other chemicals in the body, and form something called ‘comedo necrosis,’ which is basically the residual, leftover dead cells.
What does comedo type mean?
A comedo-type ductal carcinoma in situ, also known as comedocarcinoma in situ is the high grade subtype of ductal carcinoma in situ (DCIS). It completely fills and dilates the ducts and lobules in TDLU with plugs of high grade tumor cells with central necrosis “comedonecrosis”.
What is the meaning of comedo?
Definition of comedo : a small bump or blemish on the skin (as of the face or back) usually containing a plug of sebum in a skin pore: such as. a or open comedo : blackhead sense 1. b or closed comedo : whitehead.
What does comedo mean in medical terms?
What is comedo necrosis of the breast?
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
How common is comedo necrosis in DCIS?
A subtype of DCIS, comedo necrosis, associated with necrosis (cell death) was present in just over half of the cases (55%). In addition, this feature was more common in solid tumors. Both high-grade DCIS and comedo necrosis were identified more often in younger patients.
What is comedocarcinoma in situ (DCIS)?
A comedo-type ductal carcinoma in situ, also known as comedocarcinoma in situ is the high grade subtype of ductal carcinoma in situ (DCIS). It completely fills and dilates the ducts and lobules in TDLU with plugs of high grade tumour cells with central necrosis comedonecrosis.
What is the difference between high grade and low grade DCIS?
These are all different ways of describing how the DCIS looks under the microscope: DCIS that is high grade, is nuclear grade 3, or has a high mitotic rate is more likely to come back (recur) after it is removed with surgery. DCIS that is low grade, is nuclear grade 1, or has a low mitotic rate is less likely to come back after surgery.
What is intermediate grade ductal carcinoma (DCIS)?
DCIS that is intermediate grade, is nuclear grade 2, or has an intermediate mitotic rate falls in between these two. Patients with higher grade DCIS may need additional treatment. What is the significance of the reported size of the ductal carcinoma in situ (DCIS)?