What is E-cadherin in cancer?
E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue and is useful as a phenotypic marker in breast cancer, with absence of its expression frequently observed in lobular type tumors.
Do cancer cells have cadherins?
Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target. Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and differentiation throughout life.
Is E-cadherin a Tumour suppressor?
E-cadherin is a tumor suppressor protein, and the loss of its expression in association with the epithelial mesenchymal transition (EMT) occurs frequently during tumor metastasis.
What does positive for E-cadherin mean?
Sections were scored for IHC as follows: Negative, 1+ stands for weak staining, and less than 10 % of tumor cells show positive reaction for E-cadherin, 2 + stands for moderate staining, and more than 10 % show positive reaction for E-cadherin, and 3+ reflects strong staining in most of the tumor cells.
What is E-cadherin a marker for?
E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma.
Which of the following conditions is associated with decreased E-cadherin?
Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer.
Does E-cadherin play a role in gastric cancer development?
Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer.
What is the role of cadherin expression in carcinoma formation?
7. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1994; 1198 :11–26.
Does E-cadherin regulate methylation of Cdh1 in chronic gastritis?
Methylation of CDH1 has been reported to be regulated by H. pylori infection in chronic gastritis and intestinal metaplasia patients, indicating that E-cadherin plays an important role in gastric cancer initiation [ 60, 62 ].
What is the prevalence of E-cadherin (EC) mutations in intestinal cancer?
In gastric cancer, E-cadherin mutations are common in diffuse type carcinomas, but not seen in intestinal type [ 18 ].