What is a normal N-telopeptide?
The reference ranges for NTX in serum, as measured in nm BCE, are as follows : Male: 5.4-24.2. Female: 6.2-19.
What does a high N-telopeptide serum mean?
Elevated levels of N-terminal telopeptide (NTx) indicate increased bone resorption. Most patients with osteopenia or osteoporosis have low, but unbalanced, bone turnover, with bone resorption dominating over bone formation.
What does N-telopeptide serum measure?
The NTx test measures the concentration of cross-linked N-telopeptides of type I collagen. Levels of NTx correlate with the rate of bone resorption. Bone resorption rates exceeding bone formation result in a net loss of bone and ultimately osteopenia or osteoporosis.
What is N-telopeptide test?
A N-Telopeptide Cross-links Urine Test aids in the diagnosis of osteoporosis and assesses the treatment of antiresorptive therapy in patients treated for osteopenia, osteoporosis, Paget disease, or other metabolic bone disorders.
What is a telopeptide test for?
This test is used to assess the loss of bone mass (bone resorption) in cases of osteoporosis or other bone diseases such as Paget’s disease.
What is the meaning of bone resorption?
Bone resorption is the destruction of bone tissues that promotes bone loss, that is, a decrease in bone mass and bone density.
What is an N-telopeptide test?
What is a high CTX score?
Premenopausal: 25-573 pg/mL. Postmenopausal: 104-1008 pg/mL. Interpretation. Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What is high bone turnover?
High bone turnover is associated with more rapid bone loss in postmenopausal women (9) and BTMs have been studied in evaluation of this relationship. Higher BTMs are associated with bone loss from both trabecular and cortical bone at the hip and also relate to greater periosteal expansion in the femoral neck (10).
When does bone resorption occur?
During childhood, bone formation exceeds resorption. As the aging process occurs, resorption exceeds formation. Bone resorption rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause.
What does bone turnover mean?
Bone turnover (remodelling) Bone turnover is the process of resorption followed by replacement by new bone with little change in shape, and it occurs throughout a person’s life. Osteoclasts break down bone (bone resorption), releasing the minerals, resulting in a transfer of calcium from bone fluid to the blood.