What does the Sonic Hedgehog pathway do?
Sonic Hedgehog (Shh) signalling pathway is one of the major trafficking networks that regulates the key events during developmental processes i.e growth and patterning of multicellular embryos.
Is Sonic hedgehog a transcription factor?
Sonic Hedgehog Signaling SMO activation initiates transcription of GLI transcription factors which are involved in several developmental and morphogenetic processes. SHH is expressed in hindgut-derived structures including the cloacal epithelium, where it patterns the surrounding mesenchyme.
What inhibits Sonic Hedgehog?
Shh inhibitors Sonic Hedgehog (Shh) is the most potent of the three Hedgehog ligands. Inhibition of Shh expression and activity can thus be an effective way of restricting Hedgehog signaling-mediated tumor progression. RU-SKI 43 inhibits the activity of SHHat, an enzyme that catalyzes the palmitoylation of Shh.
Why is it called hedgehog?
The hedgehog was named because of its peculiar foraging methods. These animals root through hedges and other undergrowth in search of the small creatures that compose the bulk of their diet—insects, worms, centipedes, snails, mice, frogs, and snakes.
Where is Shh expressed?
In vertebrates, shh is expressed in the midline central nervous system (CNS), the notochord and the limb bud zone of polarizing activity (ZPA), and the secreted shh protein is an inductive signal in the patterning of the ventral neural tube, the anterior-posterior limb axis and the ventral somites (16–19).
What is hedgehog therapy?
ERIVEDGE® (Vismodegib of Genentech) capsule is a hedgehog pathway inhibitor indicated for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery or radiation.
Why is the sonic hedgehog gene important?
Sonic Hedgehog is necessary for the development of the front part of the brain (forebrain). This signaling protein helps establish the line that separates the right and left sides of the forebrain (the midline). Specifically, Sonic Hedgehog establishes the midline for the underside (ventral surface) of the forebrain.