What causes mannose-binding lectin deficiency?
Causes of MBL deficiency Genetic changes (known as mutations) in the MBL2 gene can lead to MBL deficiency. This gene provides instructions for making the MBL protein that plays an important role in the body’s immune response.
What is a lectin deficiency?
Mannose-binding lectin deficiency is a condition that affects the immune system. People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. Whether this deficiency makes affected individuals prone to recurrent infections is not clear.
What is MBL disease?
Mannose-binding lectin (MBL) deficiency is a condition that affects the immune system. It is a fairly common condition, affecting approximately 5–30 people in every 100. People with this condition have low levels of an immune system protein called mannose-binding lectin in their blood.
Is MBL deficiency genetic?
Conclusions: Our studies show that MBL deficiency is an inherited characteristic and may be a crucial factor in maintaining immunologic health.
Where is mannose-binding lectin found?
Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the surface of bacteria, viruses, and yeast.
What does high mannose-binding lectin mean?
The significantly elevated levels of MBL observed in chronic RHD suggest that MBL may represent a pathogenic factor in the complex physiopathology of the disease, whereas MBL deficient individuals might be less susceptible to develop chronic RHD.
Is MBL deficiency and autoimmune disease?
Interestingly, absence or extremely low concentration of serum MBL (MBL deficiency) seems to be a risk factor for occurrence of autoimmune diseases, in particular systemic lupus erythematosus. In addition, individuals with MBL deficiency are at risk of infection when in immunocompromised conditions.
Is MBL deficiency an autoimmune disease?
What is MBL in immunology?
15 Mannose binding lectin (MBL) is a member of the calcium-dependent (C-type) lectins (collectins) produced by the liver in response to infection. From: Clinical Immunology (Fourth Edition), 2013.
Where does mannose-binding lectin come from?
It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins.