What are narrow therapeutic drugs?
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
Which antibiotic has the narrowest therapeutic index?
Most antibiotics, such as the β-lactams, macrolides and quinolones have a wide therapeutic index and therefore do not require therapeutic drug monitoring. Some, such as the aminoglycosides and vancomycin, have a narrow therapeutic index, and toxicity may be severe and irreversible.
Does aspirin have a narrow therapeutic index?
However, in its use as an antirheumatic drug, the dose required to achieve the therapeutic effects is close to the dose that results in undesirable toxicity. In this situation, aspirin exhibits the characteristics of a Narrow Therapeutic Index drug.
Does heparin have a narrow therapeutic index?
Because UFH has a narrow therapeutic window and may cause bleeding complications, aggressive monitoring is necessary to ensure efficacy and patient safety. For these reasons, the Institute for Safe Medication Practices (ISMP) placed heparin on a list of high-alert medications.
Does warfarin have a narrow therapeutic window?
Warfarin has been in clinical use for nearly 60 years, and in 2010 there were over 25 million prescriptions for warfarin in the U.S. While warfarin is highly efficacious, it has a narrow therapeutic window to achieve desired anticoagulation without excess risk of bleeding.
Which of the following drug shows therapeutic window phenomenon?
Therapeutic window Medications with narrow therapeutic windows include theophylline, digoxin, lithium, and warfarin.
Why does warfarin have a narrow therapeutic range?
A dramatic account of the narrow therapeutic window for warfarin is provided by an account of the Yup’ik native Americans in Alaska, where their warfarin requirement is changed because of a naturally occurring variant in one of their cytochrome P450 enzymes (CYP4F2*3).
Does metformin have a narrow therapeutic index?
Metformin has a wide therapeutic index and is not associated with a risk for hypoglycemia when administered at the recommended doses.
What is an example of a NTI drug?
Example NTI drugs include warfarin, levothyroxine, carbamazepine, digoxin, lithium carbonate, phenytoin, and theophylline. – Small within subject variability. variances to confirm that they do not differ significantly.
Does digoxin have a narrow therapeutic range?
Digoxin has a narrow therapeutic index [1, 23, 25] so small variations in plasma concentration may readily result in toxic or sub therapeutic concentrations.
Is Methotrexate a narrow therapeutic index?
Additionally, because methotrexate is not an emergency medication, and is not a narrow therapeutic index product, lack of, or partial, administration would not be expected to result in clinically significant concerns.
What is a therapeutic window pharmacology?
Definition: The dose range of a drug that provides safe and effective therapy with minimal adverse effects. Generally, at low concentrations, a drug runs the risk of being ineffective; at high concentrations, the risk of adverse effects is increased.