Is Sweet Annie and wormwood the same thing?
But beneath its unassuming appearance, this plant – more commonly known as Sweet Wormwood or even “Sweet Annie” – biosynthesizes two potent malaria-fighting compounds called artemisinin and dihydroartemisinin, discovered in 1970 by Chinese scientist Tu Youyou.
WHO guidelines artesunate?
Per WHO guidelines, 3 doses of IV artesunate, administered intravenously over 1–2 minutes, at 12-hour intervals (0, 12, and 24 hours) is recommended for treatment of severe malaria. The dosing of IV artesunate is: 2.4 mg/kg at 0, 12, and 24 hours and can be continued daily for up to a total of 7 days, if needed.
Is sweet wormwood safe?
Thujone-free wormwood is possibly safe when used as medicine, short-term. But wormwood that contains thujone is possibly unsafe. Thujone can cause seizures, kidney failure, vomiting, and other serious side effects. When applied to the skin: Wormwood extract is possibly safe as an ointment.
What are the side effects of Artemisia annua?
Side effects of artemisinin
- skin rash.
- liver issues.
What is the English name for Artemisia annua?
Artemisia annua, also known as sweet wormwood, sweet annie, sweet sagewort, annual mugwort or annual wormwood (Chinese: 黄花蒿; pinyin: huánghuāhāo), is a common type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North America.
How do you prepare artesunate IV?
+ Slow IV injection: Dissolve 60mg of Artesunate with 1ml of 5% sodium bicarbonate solution for injection and add 5ml of 0.9% sodium chloride solution for injection before use to make 1ml contains 10mg of Artesunate.
Is artesunate FDA approved?
Today, the U.S. Food and Drug Administration approved artesunate for injection to treat severe malaria in adult and pediatric patients.
What is blackwater fever called now?
blackwater fever, also called malarial hemoglobinuria, one of the less common yet most dangerous complications of malaria. It occurs almost exclusively with infection from the parasite Plasmodium falciparum.
What is artesunate (artesunate)?
Artesunate is a weak inhibitor of OATP1B1 (IC50 = 19 mcg/mL) and OAT3. Artesunate is rapidly metabolized into an active metabolite DHA.
What is the cost of artesunate?
Artesunate is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 2.09 to 2.57 USD a dose.
What are the side effects of artesunate?
Artesunate is generally well tolerated. Side effects may include a slow heartbeat, allergic reaction, dizziness, and low white blood cell levels. During pregnancy it appears to be a safer option, even though animal studies have found harm to the baby. Use is likely fine during breastfeeding.
Can artesunate be given intravenously?
Artesunate. The intravenous form is preferred to quinidine for severe malaria. Often it is used as part of combination therapy. It is not used for the prevention of malaria. Artesunate can be given by injection into a vein, injection into a muscle, or taken by mouth. Artesunate is generally well tolerated.