How does thiazides help in nephrogenic diabetes insipidus?
Abstract. Thiazides have been used in patients with nephrogenic diabetes insipidus (NDI) to decrease urine volume, but the mechanism by which it produces the paradoxic antidiuretic effect remains unclear.
What is losartan potassium and hydrochlorothiazide used for?
Losartan and hydrochlorothiazide combination is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.
Why thiazides are contraindicated in diabetes?
Prolonged thiazide diuretic therapy can lead to glucose intolerance and may occasionally precipitate diabetes mellitus. Short-term metabolic studies, epidemiologic studies, and a variety of clinical trials suggest a connection between ongoing thiazide diuretic use and the development of type 2 diabetes.
Which diuretic is used for nephrogenic diabetes insipidus?
Nephrogenic diabetes insipidus. Treatment with the drug hydrochlorothiazide (Microzide) may improve your symptoms. Although hydrochlorothiazide is a type of drug that usually increases urine output (diuretic), it can reduce urine output for some people with nephrogenic diabetes insipidus.
Why do thiazides decrease potassium?
Part of the loss of potassium and hydrogen ion by loop and thiazide diuretics results from activation of the renin-angiotensin-aldosterone system that occurs because of reduced blood volume and arterial pressure.
What do thiazide diuretics do to potassium?
Diuretics can also affect blood potassium levels. If you take a thiazide diuretic, your potassium level can drop too low (hypokalemia), which can cause life-threatening problems with your heartbeat. If you’re on a potassium-sparing diuretic, you can have too much potassium in your blood.
Should I take potassium supplements with hydrochlorothiazide?
If you take a low dose of chlorthalidone or hydrochlorothiazide and have normal kidney function, your doctor will probably recommend getting potassium from dietary sources. You can boost your potassium intake from the same foods that are heart healthy – vegetables, fruits and fish.
Does hydrochlorothiazide increase potassium?
The drug has been widely used to treat hypertension globally and is relatively very safe. Hydrochlorothiazide acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action that lowers blood pressure, but there is also a potassium loss in the urine.
Which is better losartan potassium and hydrochlorothiazide?
Both drugs significantly lowered blood pressure, although losartan was more effective than HCTZ after a 26-month treatment (P < . 001 vP < .
Is there a difference between losartan potassium and losartan potassium hydrochlorothiazide?
Losartan increases potassium levels while HCTZ reduces potassium levels; the combination of both drugs has less effect on potassium levels.
What is a thiazide diuretic?
Thiazide diuretics What are Thiazide diuretics? Thiazide diuretics are a type of diuretic (a drug that increases urine flow). They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney).
Do thiazide diuretics increase the risk of lithium toxicity?
Thiazide diuretics can increase the risk of lithium (Eskalith, Lithobid) toxicity by reducing the kidney’s ability to eliminate lithium in the urine.
Can I take thiazide diuretics with dofetilide (Tikosyn)?
It is not recommended to use thiazide diuretics with dofetilide (Tikosyn), a drug used for treating abnormal heart rhythms, as this may increase the blood levels of dofetilide (Tikosyn) and cause abnormal heart rhythms.
What is the best time to take thiazide diuretics?
Most thiazide diuretics are taken once a day in the morning. Any reduction in blood pressure is maintained throughout the 24 hours by this once-a-day dose. However, the effect of passing extra urine wears off within 12 hours. So, you will not have to get up in the night to make extra trips to the toilet.