How do you reconstitute daptomycin?
Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution. Rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.
Can you dilute daptomycin with sterile water?
Reconstituted CUBICIN RF is compatible with Sterile Water for Injection, Bacteriostatic Water for Injection, and 0.9% sodium chloride injection. [See DOSAGE AND ADMINISTRATION (2.7).]
How is daptomycin dosed?
Dosage In Adults For cSSSI Administer CUBICIN 4 mg/kg to adult patients intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
Is daptomycin compatible with normal saline?
Our results suggest that daptomycin reconstituted vials (50 mg/mL in normal saline) and infusion solutions (5.6 and 14 mg/mL in normal saline) are physicochemically stable over a period of at least 1 week at 2–8°C.
What is the difference between Cubicin and Cubicin RF?
The major differences between Cubicin and Cubicin RF have to do with reconstitution and storage. Cubicin RF may be stored at room temperature and not at refrigerated temperatures. Cubicin requires 0.9% sodium chloride as a diluent for reconstitution whereas Cubicin RF uses sterile or bacteriostatic water.
How fast can you run daptomycin?
In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
How much is daptomycin IV?
(Generic Cubicin) Daptomycin is administered by a healthcare professional as a slow injection or as an intravenous infusion. Daptomycin cost is normally $1,490.36 for 3, 500MG Solution Reconstituted at full price. Daptomycin is administered by healthcare professionals.
What weight do you use for daptomycin dosing?
For bactericidal effect, free daptomycin concentrations should average two to four times the MIC over a 24-h period. When obtaining Food and Drug Administration (FDA) approval, daptomycin was dosed at 4–6 mg/kg of actual body weight (ABW) based on indication.
Is daptomycin compatible with lactated ringers?
Daptomycin is compatible with 0.9% sodium chloride injection and lactated Ringer’s injection and is not compatible with dextrose-containing diluents.
How long does daptomycin infusion take?
This medicine may be injected for 2 minutes (in adults only) or it may be given slowly, so the needle will have to remain in place for up to 60 minutes. To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days.
How much is zosyn IV?
The cost for Zosyn intravenous solution (2 g-0.25 g/50 mL) is around $394 for a supply of 1200 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.