Do we still need pioglitazone for the treatment of type 2 diabetes?
So, to answer our original question: yes, we still need pioglitazone for the treatment of T2DM.
Is pioglitazone and insulin?
Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin sensitizer drug for type 2 diabetes mellitus (T2DM).
How effective is pioglitazone?
Pioglitazone monotherapy showed equivalent efficacy as comparators in reducing HbA1c by 0.05% (95% CI: −0.21 to 0.11) and greater efficacy in reducing FBS level by 0.24 mmol/l (95% CI: −0.48 to −0.01).
Can you take pioglitazone with metformin?
Pioglitazone and metformin combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Pioglitazone works by helping your body use insulin better.
Is pioglitazone safe to take for diabetes?
Pioglitazone and other similar medications for diabetes may cause or worsen heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body).
Who should not take pioglitazone?
This medication isn’t good for people with uncontrolled heart failure. Actos (pioglitazone) cannot be used for people with type 1 diabetes. Sexually active premenopausal women who take Actos (pioglitazone) can get pregnant, even if they don’t have monthly periods.
Is pioglitazone better than metformin?
At endpoint, pioglitazone was significantly more effective than metformin in improving indicators of insulin sensitivity, as determined by reduction of fasting serum insulin (P = 0.003) and by analysis of homeostasis model assessment for insulin sensitivity (HOMA-S; P = 0.002). Both OAM therapies were well tolerated.
Does pioglitazone have side effects?
Common side effects may include: headache; muscle pain; or. cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
What happens if you stop taking pioglitazone?
Do not stop taking pioglitazone without talking to your doctor. If you stop taking pioglitazone suddenly, your blood sugar levels may get worse. If you want to stop taking your medicine, speak to your doctor. They may be able to suggest an alternative treatment for your diabetes.