Are NKT cells CD4+?
CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site.
What cytokines do NKT cells produce?
NKT cells can be divided broadly into CD4+ and CD4− subsets (2). In humans, this classification provides an important functional distinction, because CD4+ NKT cells make both Th1 and Th2 cytokines (such as IFN-γ, TNF, IL-4, IL-10, IL-13), whereas CD4− NKT cells primarily make Th1 cytokines (IFN-γ and TNF) (1, 3, 4).
Where do NKT cells reside?
In general, human type I NKT cells are present in small numbers (<0.1% of total T lymphocytes) in peripheral blood (PB), lymph nodes, spleen, thymus, lung, and bone marrow (32–34), whereas larger type I NKT cell populations reside in the liver, colon, kidney (~1% of total T lymphocytes) (35–37), and omentum (~10% of …
Where do NKT cells mature?
Nonetheless, these FTOC experiments confirmed that NKT cells can develop in the thymus in the absence of extrathymic factors, but did not exclude an alternative, extrathymic pathway for the development of these cells. Figure 1. CD1d-dependent NKT cell development is thymus dependent.
Are NKT cells CD4 or CD8?
13-15 NKT cells express CD4, or neither CD4 nor CD8 and are called CD4- CD8- double negative (DN). By contrast human NKT cells have a subset of NKT cells that coexpress CD8,16 further described in following sections.
What is the difference between NK and NKT cells?
Both NK and NKT cells are cytotoxic cells, which induce cell death of pathogenic cells as well as tumor cells. The main difference between NK cells and NKT cells is that NK cells are large granular lymphocytes while NKT cells are a type of T cells.
What is the role of NKT cells?
NKT cells can influence the activation state and functional properties of multiple other cell types in the immune system and, thus, modulate immune responses against infectious agents, autoantigens, tumors, tissue grafts and allergens.
Are NK cells CD4 positive?
Thus, the CD4 molecule is present and functional on NK cells and plays a role in innate immune responses as a chemotactic receptor and by increasing cytokine production, in addition to its well-described function on T cells as a coreceptor for Ag responsive cell activation.
Do NKT cells express CD4 or CD8?
Is CD4 on NK cells?